Popular Appetite Suppressant Ozempic Can Be Made For Less Than $5 a Month, New Research Suggests The $5 includes a profit margin.

By Sherin Shibu

Key Takeaways

  • Ozempic maker Novo Nordisk A/S charges almost $1,000 per month for the drug in the U.S.
  • A recent study suggests that the price could be lowered to a fraction of the current cost, while still bringing in revenue.
  • Ozempic sales brought in more than $13 billion last year, according to figures reported in the company's 2023 annual report.

Ozempic, the appetite-suppressing injection also known as semaglutide, currently costs $935.77 in the U.S. without insurance. But a new research report from Yale University, King's College Hospital in London, and Doctors Without Borders published in JAMA Network Open Wednesday suggests that the price of the prescription drug could be lowered to a fraction of what it is right now, while still generating a profit.

The researchers calculated cost-based prices for one month of Ozempic, administered as an injectable of 0.77 mg weekly, by combining commercial trade shipment data from January 1, 2016 to March 31, 2023 with the cost of creating the drug, other operating expenses, a profit margin, and tax. They found that the cost-based prices of Ozempic ranged from $0.89 to $4.73 per month.

"The findings of this study suggest that insulins, SGLT2Is, and GLP1As can likely be manufactured for prices far below current prices, enabling wider access," the researchers wrote.

A pharmacist holds a box of Novo Nordisk A/S Ozempic brand semaglutide medication. Photographer: George Frey/Bloomberg via Getty Images

Ozempic costs less outside of the U.S. — a Bloomberg report found that a month's supply of the injectable costs under $300 in Mexico.

"Outside the US, countries have different regulatory requirements with regard to the pricing of medicines, including negotiating with respective government entities," Ozempic maker Novo Nordisk told Bloomberg.

Related: FDA Has Seized 'Thousands' of Fake Units of Ozempic Amid Reported Cases of 'Adverse Reactions' in Patients

Drug markups have long come under national scrutiny, with Martin Shkreli, the former head of Turing Pharmaceuticals, forced to pay $64 million in 2022 after inflating the price of a life-saving drug by 4,000%.

Ozempic falls under the category of a GLP-1 drug, meaning that it addresses type 2 diabetes by improving blood sugar control and also potentially leading to weight loss, according to the Mayo Clinic.

Prescriptions of GLP-1 drugs increased by 300% between 2020 and 2022, Trilliant Health researchers found. Ozempic first made headlines in 2021 when it was featured on the Dr. Oz Show.

Related: Novo Nordisk, the Maker of Ozempic, Is Suing Spas and Clinics For Allegedly Selling Knockoffs

Ozempic and other similar drugs could cause an average weight loss of 15% to 20%, "significantly higher than previous options," as per Columbia Surgery.

The same publication warns of the life-long commitment Ozempic requires, as discontinuing the drug could lead to gaining all of the weight back. The drug could also cause nausea, cramps, and other unpleasant side effects.

Despite the high cost and potential downsides, Ozempic skyrocketed in popularity last year, with 66% of its more than $13 billion sales coming from the US, according to Novo Nordisk's 2023 annual report.

Related: Novo Nordisk Is Worth More Than Denmark's GDP Thanks to America's Ozempic and Wegovy Craze

Sherin Shibu

Entrepreneur Staff

News Reporter

Sherin Shibu is a business news reporter at Entrepreneur.com. She previously worked for PCMag, Business Insider, The Messenger, and ZDNET as a reporter and copyeditor. Her areas of coverage encompass tech, business, strategy, finance, and even space. She is a Columbia University graduate.

Want to be an Entrepreneur Leadership Network contributor? Apply now to join.

Editor's Pick

Business News

JPMorgan Shuts Down Internal Message Board Comments After Employees React to Return-to-Office Mandate

Employees were given the option to leave comments about the RTO mandate with their first and last names on display — and they did not hold back.

Business Ideas

70 Small Business Ideas to Start in 2025

We put together a list of the best, most profitable small business ideas for entrepreneurs to pursue in 2025.

Business News

Zillow Predicts These 10 Places Will Have the Hottest Housing Markets in 2025

Zillow predicted that the hottest housing market of 2025 will be Buffalo, New York. Here's why.

Business News

'Masculine Energy Is Good': Mark Zuckerberg Tells Joe Rogan He Thinks Companies Need More Aggression

On the most recent episode of "The Joe Rogan Experience," Meta CEO Mark Zuckerberg said corporate culture has become "neutered."

Business News

'More Soul-Crushing Than Ever': Popular Hiring Platform Finds Around 20% of Its Postings Were 'Ghost Jobs'

Is that job listing too good to be true? There's a one-in-five chance that it might be.

Growing a Business

5 Risk-Taking Lessons From Founders Who Bet Big and Won

Discover the bold moves and strategic risks that catapulted these entrepreneurs to success. Learn how their fearless decisions can inspire your own path to growth.